This is a submission for the Sanity Challenge, Path One: Ship an Agent That Queries Real Content
What I Built
Modern synthetic biology is accelerating, but physical DNA synthesizers operate with a dangerous blindspot: lack of real-time provenance verification and context-aware biosecurity threat screening.
GeneSign is an autonomous biosecurity agent and cryptographic DNA steganography engine. It screens genetic sequences against an authoritative, structured Biosecurity Knowledge Base hosted on Sanity before physical fabrication. If cleared, GeneSign embeds zero-drift, tamper-resistant watermarks into coding sequences without altering amino acid translation ($\Delta GC = 0.000\%$)[cite: 4, 14].
Key Capabilities:
- Real-time Threat Radar: Matches biological sequence motifs against regulated select agents and restricted viral strains[cite: 4, 14].
- NVIDIA Nemotron AI Rationale: Synthesizes regulatory compliance decisions and pathogen threat rationales via LLM inference[cite: 4].
- Zero-Drift Wobble Steganography: Embeds dual-layer Ed25519 cryptographic signatures utilizing synonymous codons[cite: 4, 14].
- 1-Base Mutation Interlock: Simulates physical hardware interlocks to halt synthesis immediately upon signature tampering[cite: 4, 14].
Demo
- 🌐 Live Application: genesign-biosecurity-engine-1.onrender.com[cite: 14]
- 🧬 Interface: Interactive Dark Tactical Operations HUD with real-time 3D DNA visualization and threat ledger[cite: 4, 14].
Code
- 💻 GitHub Repository: github.com/fokrulanthro16-eng/genesign-biosecurity-engine[cite: 4, 10]
How I Used Sanity
Biosecurity screening cannot rely on naive keyword search. A keyword match does not distinguish between harmless GFP reporter markers and regulated toxins or dual-use select agents.
- Structured Content Lake: High-consequence pathogen taxonomies, biosafety levels (BSL-3/4), CDC/Australia Group regulated sequence motifs, and watermarking provenance records are modeled as structured JSON schemas in Sanity.
- Sanity Context & GROQ Querying: When a user submits a FASTA sequence, the agent extracts biological coordinates and queries Sanity via GROQ to resolve relational context (homology thresholds, legal restrictions, and risk classifications).
- Agent Decision Loop: The agent feeds structured records retrieved from Sanity into NVIDIA Nemotron to generate deterministic threat rationales and trigger automated interlocks before authorizing zero-drift watermarking[cite: 4, 14].
Sanity Project Details
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Sanity Project ID:
genesign-biosecurity -
Public Dataset URL:
https://genesign-biosecurity.api.sanity.io/v2021-03-25/data/query/production?query=*[_type%20in%20[%22selectAgent%22,%20%22watermarkRecord%22]]
Content Schemas
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selectAgent: Defines regulated pathogens, organism taxonomy, risk group classifications, sequence motifs, and restriction rationales. -
watermarkRecord: Tracks cryptographic Ed25519 public keys, synthesis lab provenance, ISO/TC-276 compliance, and tamper ledgers[cite: 4, 14].
